Toothbrushing with the fluoride containing bioactive glass dentifrices had positive effects on the fluoride bioavailability within two hours. In salivary sediment bioavailability of fluoride lasted longer after application of fluoridated bioactive glass. The increase of bioactive fluoride in supernatant saliva was higher after application of NaF or AmF compared to fluoridated bioactive glass. The data were evaluated statistically using non-parametric tests. Fluoride concentration was determined in supernatant saliva and salivary sediment using a fluoride ion selective electrode. Saliva was collected time intervals before, immediately after, 30, 60 and 120 min after toothbrushing. Each group brushed their teeth either with fluoridated bioactive glass containing dentifrice, with a sodium fluoride (NaF) containing dentifrice or with amine fluoride (AmF) containing toothpaste. In this single-center, randomized, parallel in vivo trial with a three strata block design, where healthy subjects were randomly assigned into three groups.
We investigated how these effects would be apparent in an in vivo experimental trial after toothbrushing in comparison with sodium fluoride and amine fluoride. Bioactive glasses which degrade in aqueous solutions may release bioactive ions such as fluoride (F -) and support fluoride bioavailability in saliva.
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